Scientist - Translational Research

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. Were looking for people who are determined to make life better for people around the world.

Scientist - Translational Research Group, Lilly Gene Therapy

Come join the rapidly expanding Lilly Gene Therapy team at Eli Lilly! We are responsible for inventing, characterizing, and advancing novel genome therapy reagents for a myriad of clinical applications. Our team works cross-functionally within our organization across multiple disease areas and platforms. Our goal is to deliver on the promise of gene therapy to patients around the world.

The Translational Research group at Lilly Gene Therapy is seeking a Translational Research associate scientist to support the translational and bioanalytical efforts for AAV gene therapies, targeted nanoparticles and gene editing technologies. The successful candidate will perform in in vitro and in vivo studies, develop and execute experiments for our preclinical programs and analyze nonclinical data. The position requires attention to detail and ability to multitask as there are often multiple, concurrent projects. The ideal candidate will have extensive experience in molecular biology techniques, protein purification and assay development, reagent development, mammalian cell culture, and flow cytometry. This is a lab-based position.

• Plan and execute experiments in cell lines and primary cells to support our preclinical programs
• Execute in vitro, in vivo, and ex vivo experiments to test efficacy and safety of AAV vectors and nanoparticles
• Perform laboratory techniques including DNA/RNA purification and analysis (qPCR, ddPCR, RT-qPCR, NGS), protein and antibody purification, and analysis (SDS-PAGE, WES/JESS, ELISA, MSD), flow cytometry
• Run PK/PD, immunogenicity (ADA and NAb), and cell-based assays to support preclinical studies
• Develop assays and optimize methods in multiple matrices
• Support assay transfer/validation with external vendors/CROs
• Oversee stock of lab supplies, ordering and organizing lab supply inventory
• Participate in improving lab operations developing and maintaining and inventory of research samples and other reagents
• Rigorous data analysis and effective communication to all stakeholders
• Ensure research work is conducted with the highest quality and ethical standards, keeping meticulous records, and documentation
• Comply with standard laboratory practices, including documentation and biosafety policies
• Collaborate cross functionally across Lilly Research Laboratories to accelerate the development of genetic medicines

• Bachelors in Molecular biology, Biochemistry, Chemical Biology or a related scientific field with 4+ years of relevant work experience, or Masters Degree in scientific field with 2+ years of relevant work experience

• Prior training in gene therapy, and/or targeted nanoparticles
• Experience with electronic lab notebooks and/or GxP documentation
• Strong communication and collaboration skills
• Ability to work effectively in a team environment

• This role may require up to 10-15% travel for studies, conferences or training.

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Actual compensation will depend on a candidates education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lillys compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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