USA-Scientist II (Scientific)

USA-Scientist II (Scientific)#25-63618

Waltham, MA

All On-site

Job Description

Gene Therapy Structural Biologist [Contractor]

Position Overview

We are seeking a highly skilled and motivated Structural Biologist to join our team. This role will focus on elucidating the structural characteristics of AAV capsids to advance our gene therapy programs. This is a 1-year contract position, with the possibility to extend. This position is full-time on-site based in Waltham, MA.

Key Responsibilities

Design and execute structural biology experiments to characterize AAV capsid proteins

Utilize cryo-EM and other biophysical techniques to determine AAV capsid structures

Analyze structure-function relationships to guide rational design of Client AAV vectors

Collaborate with gene therapy and protein engineering teams to develop improved AAV vectors

Present findings to internal teams and at scientific conferences

Publish research in peer-reviewed journals

Qualifications

PhD (or equivalent) in Structural Biology, Biophysics, or closely related field; no post-doctoral experience necessary

Necessary expertise in cryo-EM, X-ray crystallography, or related structural biology techniques

Preferred (but not essential) experience with structural characterization of viral capsids, preferably AAV

Strong background in protein biochemistry and molecular biology

Experience with structure-based protein engineering is highly desirable

Excellent analytical, problem-solving, and communication skills

Candidates must be authorized to work in the United States

Preferred Skills

Experience with computational modeling of protein structures

Knowledge of gene therapy applications and vector development

Familiarity with high-throughput screening approaches

Track record of publications in structural biology or related fields

EEO:

Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of - Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.