Scientist III (ADME/PK/PD)

Industry: Pharmaceutical

Job Title: Scientist III (ADME/PK/PD)

Location: South San Francisco, CA 94080

Duration: 06+ Months

Pay Range: $50-$70/hr

Description:

• The Quantitative, Translational ADME Sciences (QTAS) department is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group.
• The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays for novel biologics entities.
• The successful candidate will be experienced in the development, optimization and implementation of novel and routine LC/MS-based bioanalytical methods to support in vivo PK, TK, and PK/PD studies as well as in vitro stability characterization of therapeutic proteins, peptides, and oligonucleotides.
• The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation.
  
  

• Operate and maintain LC/MS instruments to generate high-quality experimental data.
• Perform affinity purification of therapeutic proteins (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices.
• Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
• Facilitate assay optimization and implementation to ensure laboratory capacity and data quality.
• Communicate data interpretation internally and externally.

• BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry.
• Degree in chemistry, pharmacology or other related fields.
• Hands-on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers
• Experience on routine LC/MS-based bioanalysis to support in vivo PK, TK, and PK/PD studies.
• Hands-on experience with automated liquid handling systems is highly desired.
• Hands-on experience with oligonucleotide analysis is highly desired.
• Prior industry experience in drug discovery/development is preferred. In-depth understanding of PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired.
• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor

• LC-MS
• LCMS
• Mass spectroscopy
• QQQ
• SCIEX
• qTOF
• Orbitrap
• Oligonucleotides
• PK/PD
• ADME
• Pharmacokinetics
• Pharmacodynamics