Sr Principal Scientist, Immuno-Oncology (In vivo)

  • Regeneron Pharmaceuticals
  • Tarrytown, New York
  • Full Time

Regeneron is seeking a highly motivated Sr. Principal Scientist to contribute to the discovery and validation of exciting novel therapeutic approaches aimed at harnessing the immune system to treat cancer. You will work with and across several functional teams to coordinate and drive pre-clinical research efforts at Regeneron.

A typical day in the life of a Sr. Principal Scientist may consist of the following:

  • Design, plan, and supervise/perform complex anti-tumor efficacy studies in mice
  • Document experimental procedures and results in a well-organized fashion; generate experimental reports and write manuscripts for journal submission
  • Compile results across experiments and programs and present research strategy/results and participate in scientific discussion with multi-disciplinary teams and senior leadership.
  • Performing deep dives on potential targets
  • Interfacing with colleagues from different therapeutic focus areas at Regeneron
  • Following current relevant literature and attending scientific conferences to seek out, recognize, and assess novel biology and technologies in this space

This job may be for you if you have the following:

  • Have a PhD in Immunology, Oncology, or Immuno-Oncology with 10+ years experience (at least 4 years post-doctoral experience and 3 plus years of industry experience in Immunology and/or Immuno-Oncology) or MS in Immunology, Oncology or I/O with 15+ years of relevant industry experience.
  • Experience with development of novel Immunotherapeutics, in vivo testing, and multi-color flow cytometry is strongly preferred
  • Prior experience with antibody technology or development is a plus
  • Possess strong and critical data analysis and interpretation skills
  • Have a proven track record of success working in a matrix/cross functional environment
  • Are a strong and generous collaborator, who enjoys engaging colleagues across disciplines
  • Have leadership strengths and can effectively communicate and navigate in a matrix environment
  • Possess excellent written/oral communication and interpersonal skills

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$148,300.00 - $241,900.00

Job ID: 488580916
Originally Posted on: 8/8/2025

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