Research - Senior Associate Scientist I

Title: Senior Associate Scientist I
Location : Cambridge, MA
Duration: 5 + Months
Possibility of extension: Yes

Position Summary:
Client is seeking a Senior Associate Scientist I to support oligonucleotide drug substance development. The ideal candidate will have hands-on experience in chemical synthesis and downstream processing, as well as a strong understanding of analytical techniques relevant to oligonucleotide production. Key Responsibilities:

• Perform chemical synthesis of oligonucleotides at scales up to 11 mmol
• Conduct downstream processing activities including:
  • Preparative HPLC
  • Ultrafiltration
  • Annealing
  • Concentration
  • Lyophilization
• Execute in-process analytical testing using:
  • Anion exchange HPLC (AX-HPLC)
  • Ion-pair reversed-phase HPLC (IPRP-HPLC)
  • LC-MS
  • UV-Vis spectroscopy
• Provide technical support for process optimization in collaboration with contract manufacturing organizations (CMOs)
• Maintain accurate and timely lab documentation in accordance with best practices

Qualifications:

• Education: Bachelor's degree in Chemistry or related discipline
• Experience: Minimum 3 years of hands-on laboratory experience, preferably in an industrial or pharmaceutical setting
• Strong understanding of key analytical techniques including HPLC, LC-MS, pH, osmolality, and conductivity measurements
• Familiarity with oligonucleotide synthesis processes (phosphoramidite chemistry, chromatography, ultrafiltration) is highly desirable
• Excellent record-keeping skills and adherence to good laboratory documentation practices (GLP/GMP)
• Strong organizational and communication skills
• Demonstrated ability to work effectively in a fast-paced, team-oriented environment

Additional Requirements:

• Skill Set: Oligonucleotide synthesis and downstream processing, analytical instrumentation (HPLC, LC-MS, UV-Vis)
• Must be proactive, reliable, and safety-conscious
• Ability to contribute to a dynamic R&D environment with tight deadlines

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