Scientist I/Scientist II - Biologics Discovery

Scientist I/Scientist II - Biologics Discovery

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Molecular Design & Development

Level:

Scientist I-II

Location:

HQ - Foster City, CA

Reporting Manager:

Senior Scientist I, Biologics Discovery

About the Opportunity:

We are seeking an energetic, self-motivated, collaborative Scientist I/Scientist II to join our Biologics research group of the Molecule Design & Development department dedicated to the discovery and development of novel oncology therapeutics. The position initially will primarily support protein engineering, production, and analytic functions with occasional support of cell biology as needed. A major component of the role involves understanding the protein needs of early-stage projects and therapeutic areas along with coordination of delivery with project teams. Title, compensation and scope of duties will be tailored to the successful candidate's experience.

Role and Responsibilities:

• Protein production of antibodies and bispecifics using transiently expressing cell lines (experience with Expi293, ExpiCho and AKTA machines is appreciated).

• Develop technical solutions to problems, keep abreast of industry best practices and technological advancements in biologics manufacturing.

• Design, execute, and oversee protein binding assays, kinetic assays, and biophysical analyses to support characterization and discovery workflows (SEC, CE-SDS, BLI, SPR, ELISA skillsets appreciated).

• Work independently and collaboratively in a small team environment

• Manage and mentor Research Associates and junior laboratory personnel

• Maintenance of HEK and CHO cell lines (both stable and transient)

• Protein characterization (affinity determination, competitive binding assays, epitope determination) by plate-based methods (ELISA)

Education, Experience and Qualification Requirements:

• Ph.D. in cell biology, Immunology, molecular biology, or a related field with minimum of 2 years relevant industry experience; or M.S. with 6+ years; or B.S. with 8+ years

• Fundamental knowledge of proteins and antibodies

Core Competencies, Knowledge and Skill Requirements:

• Transfection of transient mammalian cell linles (HEK & CHO).

• Experience with protein purification and QC (Gravity column purification and AKTA)

• Experience with protein analysis (HPLC, BLI, Endotox, ect).

• Experience with reagent documentation. Organizational skills, and teamwork/communication skills are required.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company's total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $120,000 and $140,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio's Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.