Principal Scientist Jobs in South San Francisco, CA
A Principal Scientist in the chemistry industry is responsible for conducting complex research, developing new procedures, and overseeing a team of scientists to ensure all projects are completed to a high standard. They typically perform experimental tests and analyses, interpreting and presenting results, and preparing research reports and scientific papers. Their work is instrumental in contributing to the development of new products, technologies, or intellectual property. They often work closely with other departments such as Regulatory Affairs, Quality Control, and Manufacturing to ensure all scientific operations meet the necessary standards and regulations.
Important skills for a Principal Scientist include leadership, excellent written and oral communication abilities, strong analytical skills, and the ability to work well in teams. They should have a thorough understanding of various scientific techniques and principles, and be adept at problem-solving. The minimum requirement for this position is typically a PhD in Chemistry or a related field, with substantial experience in the industry. Certifications that can add value include Certified Professional Chemist (CPC) or Certified Clinical Research Professional (CCRP). A person might work as a Research Scientist, Senior Scientist, or Project Leader before moving into the role of a Principal Scientist.
Associate Principal Scientist, Respiratory Discovery
- Merck Company
- South San Francisco, CA
- 1 day ago
- South San Francisco, CA
- 1 day ago
We are seeking an Associate Principal Scientist with strong expertise in respiratory biology and translational research to contribute to target discovery, validation, and translational biology strategy...
In PersonSenior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational Medicine
- Bristol Myers Squibb
- Brisbane, CA (2 miles from South San Francisco, CA)
- 1 day ago
- Brisbane, CA (2 miles from South San Francisco, CA)
- 1 day ago
R1601688 : Senior Principal Scientist, Neuroscience, Clinical Biomarker, Late Phases, Translational Medicine...
HybridPrincipal Scientist, Protein Sciences, Analytical Characterizations
- Valid8 Financial, Inc.
- San Francisco, CA (8 miles from South San Francisco, CA)
- 2 days ago
- San Francisco, CA (8 miles from South San Francisco, CA)
- 2 days ago
Principal Scientist, Protein Sciences, Analytical Characterizations September 2025 Department: Technology Position Summary: TCG Labs-Soleil is seeking a highly experienced and driven Principal Scientist...
In PersonPrincipal Scientist, Computational Chemistry
- Eikon Therapeutics, Inc.
- Millbrae, CA (4 miles from South San Francisco, CA)
- 4 days ago
- Millbrae, CA (4 miles from South San Francisco, CA)
- 4 days ago
Position We seek a Principal Scientist in Computational Chemistry with a demonstrated ability of successfully applying in silico technologies to drive the discovery of quality lead-like molecules against...
In PersonPrincipal Scientist, Purification Process Development
- Denali Therapeutics
- South San Francisco, CA
- 6 days ago
- South San Francisco, CA
- 6 days ago
Design and execute lab-scale chromatography and filtration studies to inform and support large scale process decisions Maintain existing workflows to provide purification support for cell line and cell...
In PersonPrincipal Scientist - PKDM, Modeling and Simulation
- Amgen
- South San Francisco, CA
- 7 days ago
- South San Francisco, CA
- 7 days ago
The Principal Scientist we seek is a self-driven, dynamic team member with these qualifications....
In PersonPrincipal Scientist - Medicinal Chemistry
- Nurix Therapeutics
- San Francisco, CA (8 miles from South San Francisco, CA)
- 7 days ago
- San Francisco, CA (8 miles from South San Francisco, CA)
- 7 days ago
Expert in organic synthesis, knowledgeable of the current literature, with strong synthetic problem-solving skills....
In PersonPrincipal Scientist, Biomarker Data Sciences
- Biogen
- San Francisco, CA (8 miles from South San Francisco, CA)
- 8 days ago
- San Francisco, CA (8 miles from South San Francisco, CA)
- 8 days ago
About This Role: As a Principal Scientist in Biomarker Data Sciences within the Clinical Biomarkers group at the West Coast Hub, you will lead the charge in multi-omics analyses of extensive clinical...
In PersonPrincipal Scientist, Process Development
- Gilead Sciences
- Foster City, CA (11 miles from South San Francisco, CA)
- 12 days ago
- Foster City, CA (11 miles from South San Francisco, CA)
- 12 days ago
Job Description Principal Scientist, Purification Development - Pre-Pivotal Biologics Foster City, CA Principal Scientist, Purification Process Development (Pre-Pivotal) will be responsible for leading...
In PersonPrincipal Scientist - Agentic Product
- Adobe
- San Francisco, CA (8 miles from South San Francisco, CA)
- 12 days ago
- San Francisco, CA (8 miles from South San Francisco, CA)
- 12 days ago
As a Principal Scientist (Engineering), Agentic Product, you will be a key technical leader for Adobe's up-and-coming AI-native experience that brings generative models, creative intelligence, and decades...
In PersonSenior/Principal Scientist In Vivo Pharmacology
- Kodiak Sciences Inc
- Palo Alto, CA (21 miles from South San Francisco, CA)
- 13 days ago
- Palo Alto, CA (21 miles from South San Francisco, CA)
- 13 days ago
Kodiak Sciences is seeking a highly motivated and independent Senior/Principal Scientist to join the In Vivo Pharmacology team....
In PersonPrincipal Scientist, Cancer Pharmacology, Translational Research
- Revolution Medicines, Inc.
- Redwood City, CA (16 miles from South San Francisco, CA)
- 13 days ago
- Redwood City, CA (16 miles from South San Francisco, CA)
- 13 days ago
The Opportunity: As a Principal Scientist in the Cancer Pharmacology team within the Translational Research group, in the Biomedical Discovery Research Department, you will: Provide scientific and strategic...
HybridPrincipal Scientist, Clinical Biomarkers
- Biogen
- San Francisco, CA (8 miles from South San Francisco, CA)
- 14 days ago
- San Francisco, CA (8 miles from South San Francisco, CA)
- 14 days ago
About This Role: As a Principal Scientist in Clinical Biomarkers, you will play a pivotal role in the design, execution, and interpretation of biomarker activities across our clinical studies....
In PersonPrincipal Scientist PKDM (Large Molecule Project Team Representative)
- Amgen
- South San Francisco, CA
- 15 days ago
- South San Francisco, CA
- 15 days ago
Principal Scientist PKDM (Large Molecule Project Team Representative) What you will do Lets do this. Lets change the world....
In PersonAssociate Principal Scientist, In Vivo Pharmacology
- Merck Company
- South San Francisco, CA
- 15 days ago
- South San Francisco, CA
- 15 days ago
Our company's Research Laboratories in South San Francisco is seeking a highly motivated and accomplished Associate Principal Scientist to join our Quantitative Biosciences (Pharmacology) department...
In PersonDemographic Data for South San Francisco, CA
Moving to South San Francisco, CA? Find some basic demographic data about South San Francisco, CA below.
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Principal Scientists in South San Francisco, CA offer the following education backgroundQualifications / Skill Sets
The following top skills are often required or desired to land a Principal Scientist position
- Personal Protective Equipment
- Chromatography
- Method Development
- Liquid Chromatography
- High-Performance Liquid Chromatography
- Analytical Chemistry
- Assay Development
- Scale-Up
- Rheology
- Purification
- Analytical Method Transfer
- Liquid Chromatography Mass Spectrometry
- Medicinal Chemistry
- Cell-Based Assays
- Cell Biology
- Biomarkers
- Proteomics
- Dynamic Light Scattering
- Peptide Synthesis
- Mass Spectrometry
- Clinical Laboratory Operations
- Chemical Characterization
- ICP-MS
- Biochemistry
- Fourier Transform Infrared Spectroscopy
- Organic Chemistry
- Drug Development
- Ultra Performance Liquid Chromatography
- Drug Discovery
- Experimental Design
- Cell Culture
- Molecular Biology
- Toxicology
- Immunology
- Laboratory Management
- Research and Development
- Validation
- Biotechnology
- Biology
- Optimization
- Process Development
- Clinical Trials
- Good Manufacturing Practices
- Hazardous Materials
- Oncology
- Modeling
- Standard Operating Procedures
- Product Development
- Engineering
- Quality Control
- Troubleshooting
- Investigation
- Documentation
- Quality Assurance
- Mentoring
- Implementation
- Reporting
- Data Analysis
- Collaboration
- Education Experience
- Bachelor's Degree
- Regulations
- Research Skills
- Staff Supervision
- Problem Solving
- Scheduling
- Leadership
- Communication Skills
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