Senior Scientist, Conjugation

Why Patients Need You

Pfizers purpose is to deliver breakthroughs that change patients lives. Research and Development is at the heart of fulfilling Pfizers purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines and vaccines to patients around the world.

What You Will Achieve

As a Senior Scientist in the Early Bioprocess Development within Pfizer Vaccines, you will be at the center of our operations and youll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a large team of Scientists focused on conjugation process development for manufacturing carbohydrate-based conjugate vaccines. Primary duties include development of new/novel conjugation methods, analysis of glycoconjugates, and optimization of conjugation process parameters including conjugation and purification. Experience in the preparation of glycoconjugates is highly desired. The individual will become a key contributor towards the early development and scale up of glycoconjugate vaccines. Careful documentation of work and presentation of data is required. All work is to be done in a compliant manner according to SOP guidelines and cGMP/GLP regulations, where applicable.

How You Will Achieve It

• Develop, optimize and scale-up conjugation process for glycoconjugate vaccine candidates.

• Independently plan and execute experiments for conjugate vaccine candidates, and lead the development on special projects, when required.

• Present periodic status updates to the group, discuss problems and propose solutions in discussion with group members. Offer insights based on experience to group members to help solve problems.

• Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess, Analytical, and Formulation Development groups.

• Keep abreast of scientific/technological development by participating in scientific meetings/seminars and through regular scientific review. Utilize new technologies and establish those technologies to improve conjugation process

• Continuously evaluate each process and technique to determine if it is robust, appropriate, and scalable. If an operation has shortcomings or can be improved, uses expertise and imagination to suggest improvements.

• Participate in the technology transfer of developed process to the clinical manufacturing site, both internally and externally, and provide the technical support as needed.

• Fully document laboratory experiments in electronic notebook in a timely and compliant manner and prepare technical reports as needed.

Qualifications

Must Have

• PhD degree in Organic Chemistry/Carbohydrate Chemistry or Biochemistry with 0 to 3 years of experience OR an MS degree in Chemistry with a 7 to 8 years relevant carbohydrate experience.

• Experiences with conjugation, purification processes and glycoconjugate analytical techniques

• Understanding of the design, planning, and execution of conjugation and purification activities including the operation and maintenance of relevant instruments, resolution of technical problems related to instruments, and execution of analytical/biophysical characterization methods.

• Experience with a variety of state-of-the-art analytical techniques including NMR, Mass Spectrometry etc. and other analytical techniques.

• Independently analyze and provide conclusions regarding experimental data generated.

• Proficiency with personal computers including word processing, spreadsheets, PowerPoint, and relevant scientific software

• Strong verbal and written communication skills are required.

• Experience with documentation of laboratory notebook in an electronic format.

Other Job Details

• Work Assignment: Onsite

The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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