Research Associate, Oligonucleotide Chemistry

Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body's natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro's lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.

We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.

Key Responsibilities:

• Execute solid-phase synthesis, purification, and downstream processing of chemically modified oligonucleotides and oligonucleotides conjugates at different scales using modern automated oligo synthesis platforms
• Operate, maintain & troubleshoot equipment for oligonucleotide synthesis (Mermade 12), purification (KTA Pure), desalting and lyophilization
• Ability to cross-train with other synthesis scales and instrumentation (Mermade 192)
• Maintain inventory of chemicals and amidites for oligonucleotide synthesis
• Perform in-process and final analytics of oligonucleotide samples as needed
• Track progress, analyze, organize, and present data to team and cross-functionally
• Maintain a well-documented electronic laboratory notebook
• Actively participate in training activities and provide training to others as needed
• Author and review SOPs and technical reports

Required Qualifications:

• BS/MS with 1+ years experience in Chemistry, Biochemistry, Biotechnology, or related field
• Hands-on experience in the synthesis, purification, solid-liquid conjugation, and analysis of oligonucleotides
• Oligonucleotide process development experience is a plus
• Strong laboratory skills and experience in handling, troubleshooting and routine maintenance of lab equipment including automated synthesis platforms, HPLC and LC-MS etc.
• High degree of flexibility and self-motivation in a fast-paced work environment with excellent organizational skills, ability to prioritize appropriately and meet deadlines.
• Excellent interpersonal, communication and presentation skills.
• Detail-oriented and excellent problem-solving abilities.

Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account and a Company-funded health savings account and free parking.