Associate Scientist II - Oligonucleotide Synthesis
- Spectraforce Technologies Inc
- Lexington, Massachusetts
- Full Time
Associate Scientist II - Oligonucleotide Synthesis
Lexington, MA
Date Posted:23-Jun-2025
Work Type:On-Site
Job Number:458290
Job Description
Job Title: Associate Scientist II - Oligonucleotide Synthesis
Location: Lexington, MA
Duration: 1 yr (possibility to extend)
Reporting Expectations: Onsite/lab, M-F 8-5
Top Skills per Manager:
LC/MS experience /oligo method development
Mass Spec Maintenance and trouble shooting
Oligonucleotide Purification
Job Description:
About the Department
The Global Nucleic Acid Therapies area strives to be a global leader in nucleic acid therapeutics by developing innovative technology platforms and molecules that trans-late into novel genetic medicines to improve patients' lives.?
Our mission is to bring curative and disease modifying therapies to individuals living with serious chronic conditions.?We are a global team with locations in Massachusetts (Greater Boston Research & Early Development Hub), Colorado and Copenhagen, pushing technological innovation to expand the RNA and gene therapy application space. Our proprietary GalXC and GalXC-Plus RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. The value chain spans from early research to phase 1 clinical studies.
Nucleic Acids Research is a unique organization within client Research & Early Development that brings together the best of both worlds - the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. We are a team of inventive and entrepreneurial thinkers pushing the boundaries of science. Together, we are driving change. Are you ready to make a difference?
The Position
Client is seeking a highly motivated Associate Scientist II to join the Oligonucleotide Chemistry Team in Lexington, Massachusetts. The candidate will be responsible for analysis and purification of oligonucleotides.
This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms.
Prior experience in LCMS method development and oligonucleotide purification and characterization is desired.
Relationships
This position reports to the Director, Oligonucleotide Chemistry as an individual contributor.
Daily interaction with other peers in oligo synthesis, medicinal chemistry and biology teams in support of early phase product pipeline.
Essential Functions
Primary responsibility to provide analytical lab support for client's Oligonucleotide early phase pipeline
Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances.
Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS
Operate, maintain and troubleshoot lab instruments
Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA
Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports
Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs
Oligonucleotide synthesis
Possess excellent written and verbal communication skills
Conduct laboratory work in an efficient manner that ensures a safe working environment
Qualifications
MS or BS with 3+ years of industrial experience
Strong knowledge of mass spectrometry and purification techniques
Experience with waters LC/MS instruments preferred
Experience with purification and LC/MS analysis of sgRNA highly preferred
Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation
Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics
Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC's and associated software
In depth knowledge of GLP/GMP's in a pharmaceutical environment
The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams
Applicant Notices & Disclaimers
For information on benefits, equal opportunity employment, and location-specific applicant notices, click here
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position's starting pay is: $44.72/hr.
Lexington, MA
Date Posted:23-Jun-2025
Work Type:On-Site
Job Number:458290
Job Description
Job Title: Associate Scientist II - Oligonucleotide Synthesis
Location: Lexington, MA
Duration: 1 yr (possibility to extend)
Reporting Expectations: Onsite/lab, M-F 8-5
Top Skills per Manager:
LC/MS experience /oligo method development
Mass Spec Maintenance and trouble shooting
Oligonucleotide Purification
Job Description:
About the Department
The Global Nucleic Acid Therapies area strives to be a global leader in nucleic acid therapeutics by developing innovative technology platforms and molecules that trans-late into novel genetic medicines to improve patients' lives.?
Our mission is to bring curative and disease modifying therapies to individuals living with serious chronic conditions.?We are a global team with locations in Massachusetts (Greater Boston Research & Early Development Hub), Colorado and Copenhagen, pushing technological innovation to expand the RNA and gene therapy application space. Our proprietary GalXC and GalXC-Plus RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. The value chain spans from early research to phase 1 clinical studies.
Nucleic Acids Research is a unique organization within client Research & Early Development that brings together the best of both worlds - the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. We are a team of inventive and entrepreneurial thinkers pushing the boundaries of science. Together, we are driving change. Are you ready to make a difference?
The Position
Client is seeking a highly motivated Associate Scientist II to join the Oligonucleotide Chemistry Team in Lexington, Massachusetts. The candidate will be responsible for analysis and purification of oligonucleotides.
This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms.
Prior experience in LCMS method development and oligonucleotide purification and characterization is desired.
Relationships
This position reports to the Director, Oligonucleotide Chemistry as an individual contributor.
Daily interaction with other peers in oligo synthesis, medicinal chemistry and biology teams in support of early phase product pipeline.
Essential Functions
Primary responsibility to provide analytical lab support for client's Oligonucleotide early phase pipeline
Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances.
Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS
Operate, maintain and troubleshoot lab instruments
Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA
Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports
Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs
Oligonucleotide synthesis
Possess excellent written and verbal communication skills
Conduct laboratory work in an efficient manner that ensures a safe working environment
Qualifications
MS or BS with 3+ years of industrial experience
Strong knowledge of mass spectrometry and purification techniques
Experience with waters LC/MS instruments preferred
Experience with purification and LC/MS analysis of sgRNA highly preferred
Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation
Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics
Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC's and associated software
In depth knowledge of GLP/GMP's in a pharmaceutical environment
The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams
Applicant Notices & Disclaimers
For information on benefits, equal opportunity employment, and location-specific applicant notices, click here
At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws. This position's starting pay is: $44.72/hr.
Job ID: 483006636
Originally Posted on: 6/27/2025
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