Associate Scientist II

Associate Scientist II

Payrate:

$40.00 - $44.72/hr.

Summary:

We are seeking a highly motivated Associate Scientist II to join the Oligonucleotide Chemistry Team in Lexington, Massachusetts. The candidate will be responsible for analysis and purification of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of Client nucleic acid conjugate platforms. Prior experience in LCMS method development and oligonucleotide purification and characterization is desired.

Responsibilities:

Primary responsibility to provide analytical lab support for Oligonucleotide early phase pipeline

Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances.

Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS

Operate, maintain and troubleshoot lab instruments

Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA

Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports

Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs

Oligonucleotide synthesis

Possess excellent written and verbal communication skills

Conduct laboratory work in an efficient manner that ensures a safe working environment

Qualifications:

MS or BS with 3+ years of industrial experience

Strong knowledge of mass spectrometry and purification techniques

Experience with waters LC/MS instruments preferred

Experience with purification and LC/MS analysis of sgRNA highly preferred

Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics

Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC s and associated software

In depth knowledge of GLP/GMP s in a pharmaceutical environment

The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams

Pay Transparency:

The typical base pay for this role across the U.S. is:

$40.00 - $44.72/hr.

Final offer amounts, within the base pay set forth above, are determined by factors including your relevant skills, education and experience and the benefits package you select. Full-time employees are eligible to select from different benefits packages. Packages may include medical, dental, and vision benefits, 10 paid days off, 401(k) plan participation, commuter benefits and life and disability insurance.

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Dice Id:

10111892

Position Id:

25-20268