Senior Scientist - Gene Therapy

• The Structural Biologist will focus on elucidating the structural characteristics of AAV capsids to advance gene therapy programs.
• This role involves using cryo-EM and other biophysical techniques to analyze AAV capsid structures and guide the rational design of novel AAV vectors.
• The successful candidate will work closely with gene therapy and protein engineering teams.

Responsibilities or Duties:

• XXgn and execute structural biology experiments to characterize AAV capsid proteins.
• Utilize cryo-EM and other biophysical techniques to determine AAV capsid structures.
• Analyze structure-function relationships to guide the design of novel AAV vectors.
• CollaboXX with gene therapy and protein engineering teams to develop improved AAV vectors.
• Present findings to internal teams and at scientific conferences.
• Publish research in peer-reviewed journals.

Qualification or Education:

• Ph.D. (or equivalent) in Structural Biology, Biophysics, or a closely related field; no post-doctoral experience necessary.

Experience:

• Expertise in cryo-EM, X-ray crystallography, or related structural biology techniques.
• Strong background in protein biochemistry and molecular biology.
• Experience with structure-based protein engineering (highly desirable).

Required Skills:

• Excellent analytical, problem-solving, and communication skills.
• Candidates must be authorized to work in the United States.

Preferred Skills:

• Experience with computational modeling of protein structures.
• Knowledge of gene therapy applications and vector development.
• Familiarity with high-throughput screening approaches.
• Track record of publications in structural biology or related fields.