Assay Development Research Associate

ABOUT US

There are more than 9 million immunocompromised people in the United States. Almost half a million of those represent a population that are moderately to severely immunocompromised and at highest risk for severe COVID-19, including stem cell and solid organ transplant patients as well as those with hematologic cancers.

At Invivyd, Inc., we take those numbers very seriously and we come to work each day on a mission to deliver protection from serious viral infectious diseases, beginning with SARS-CoV-2. Invivyd deploys a proprietary integrated technology platform unique in the industry designed to assess, monitor, develop, and adapt to create best in class antibodies. In March 2024, Invivyd received emergency use authorization (EUA) from the U.S. FDA for a monoclonal antibody (mAb) in its pipeline of innovative antibody candidates.

Join an incredible team of innovators, disrupters, predictive modelers, and antibody engineers who embrace a shared sense of ownership, a passion to save lives, think boldly and creatively, take targeted risks, are unafraid of failure, and welcome change as a positive catalyst to new opportunities.

Be part of making a difference. Be part of Invivyd.

Position Title: Assay Development Research Associate

Position Summary:

In this role you will develop and execute functional assays for a cutting-edge antibody discovery platform. This involves applying a breadth of techniques in the virology, molecular biology, cell biology, and immunology spaces to advance innovative biotherapeutic products through discovery and pre-clinical development stages at Invivyd. This is a unique opportunity to join Invivyd's Antibody Discovery and Preclinical Development Team which generates and characterizes human therapeutic antibody candidates against infectious disease targets like SARS-CoV-2, influenza, and RSV. The Assay Development Research Associate will serve as a key member of the discovery team, provide expert input, and execute new and established methods to meet project requirements and timelines.

Responsibilities:

• Development and troubleshooting of virus-based antibody screening functional assays and optimization of existing assays.
• Contribute to high-impact projects within the Discovery group by characterizing lead antibody molecules for pre-clinical studies.
• Perform experiments involving in vitro screening and characterization of antibody drug candidates using immunological, biochemical, and cell-based assays.
• Generate pseudoviruses for use in evaluation of antibody candidates.
• Generate authentic viruses in a BSL-2 setting for use in evaluation of antibody candidates.
• Participate in the molecular design and characterization of DNA constructs used for assay development.
• Execute basic molecular biology (DNA manipulation such as RNA extraction, RT-PCR, PCR, cloning, etc.) and Cell Biology (mammalian cell culture, gene transfection and expression) to support antibody discovery efforts.
• Collaborate closely across an interdisciplinary biologics research team to drive antibody discovery campaigns.
• Employ high-throughput molecular biology methods for building new vectors and libraries.
• Maintain appropriate records e.g. lab notebook, protocols, reports, data integrity.
• Present data, both orally and as written reports, to internal stakeholders.

Requirements:

• Master's degree or Bachelor's degree and 4+ years of bench Industry experience in virology, molecular biology, cell biology, or other life science disciplines.
• High proficiency in mammalian cell culture is required.
• Previous experience working with virus in a BSL-2 setting is required.
• Previous experience with cell-based assays and functional antibody characterization is highly preferred.
• Mammalian cell transfection with an understanding of expression vector design is highly preferred.
• Strong understanding of molecular biology and experience with DNA construct design and sequence analysis is highly preferred.
• Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time.
• Ability to interpret in-process readouts for the purposes of assay optimization and troubleshooting.
• Excellent verbal and written technical and non-technical communication skills.

At Invivyd we strive to create a welcoming and inclusive environment. Here all applicants will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics.

Invivyd is proud to be an equal opportunity employer.

We do not accept unsolicited resumes from agencies.